Biology for the post-genomic era

Genome Biology publishes research articles, new methods and software tools, in addition to reviews and opinions, from the full spectrum of biology, including molecular, cellular, organism or population biology studied from a genomic perspective, as well as sequence analysis, bioinformatics, proteomics, comparative biology and evolution.


  • Clare Garvey PhD, Genome Biology


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  • Wilms tumor biomarkers

    Methylome analysis of Wilms tumor identifies differentially methylated biomarker regions that can be detected in cell-free circulating DNA

    Genome Biology 2014, 15:434
  • R2TP chaperone acitivty

    This study in yeast explores the molecular basis of how the R2TP complex is required for box C/D snoRNP assembly

    Genome Biology 2014, 15:404
  • B-cell lymphoma relapse

    Sequencing of VDJ rearrangements and analysis of somatic hypermutations reveals two distinct clonal evolution modes in diffuse large B-cell lymphoma

    Genome Biology 2014, 15:432
  • Lung cancer lncRNAs

    Many lung cancer-associated lncRNAs and their role in tumorigenesis  are revealed in a transcriptional analysis

    Genome Biology 2014, 15:429
  • Genomic data sharing

    Bartha Knoppers and colleagues discuss the data-sharing models that can inform genomic data-sharing strategies

    Genome Biology 2014, 15:430
  • Genomics to clinics

    Michael Berger and Anna Varghese describe the difficulties we face when translating genomic cancer research into the clinical setting

    Genome Biology 2014, 15:427
  • Cancer sequencing biases

    A new single molecule tagging method helps identify PCR duplicates and simplifies analyses of clonal evolution and heterogeneity in cancer

    Genome Biology 2014, 15:420
  • Image attributed to: MethylPurify


    A new method for tumor purity analysis and differential methylation detection in a single tumor sample

    Genome Biology 2014, 15:419
  • Image attributed to: MBASED


    A new method for effective allele-specific expression detection when no genotype is available

    Genome Biology 2014, 15:405
  • Glucocorticoid receptor binding

    A new analysis of glucocorticoid receptor binding motifs identifies monomeric binding to half-sites

    Genome Biology 2014, 15:418
  • SUMO-specific protease family

    Stefan Müller and Arnab Nayak review the versatile protein family of SUMO-specific proteases / isopeptidases

    Genome Biology 2014, 15:422

Featured free review

The indoor microbiomeThe indoor microbiome

Scott Kelley and Jack Gilbert review the microbiology of the built environment, and highlight how genomics can empower its study.



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Dog genomics helps medical research
Beyond the Genome: Cancer Genomics 2014

Latest issue

Genome Biology Volume 15 Issue 7

The complete issue of Genome Biology Volume 15 Issue 7 is now available.

Free webinar on plant genomics:

Breeding opportunities out of challenges, broadcast live 18th April 2013 sponsored by Affymetrix. A free to view panel discussion between Clare Garvey, Editor – Genome Biology, BioMed Central, Etienne Paux, INRA and Doreen Ware, USDA ARS, Adjunct Associate Professor, Cold Spring Harbor Laboratory.

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ISSN: 1465-6906