Biology for the post-genomic era

Fully Open Access. Genome Biology covers all areas of biology and biomedicine studied from a genomic and post-genomic perspective. Content includes research, new methods and software tools, and reviews, opinions and commentaries. Areas covered include, but are not limited to: sequence analysis; bioinformatics; insights into molecular, cellular and organismal biology; functional genomics; epigenomics; population genomics; proteomics; comparative biology and evolution; systems and network biology; genomics of disease; and clinical genomics. All content is open access immediately on publication.


  • Louisa Flintoft PhD, Genome Biology


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  • Colon cancer 5hmC

    Promoters 5-hydroxymethylated during normal colon differentiation are resistant to neoplastic hypermethylation

    Genome Biology 2015, 16:69
  • Colorectal cancer immunophenotypes

    Analysis of colorectal cancer immunophenotypes reveals a tumor escape mechanism and identifies novel cancer immunotherapy candidates

    Genome Biology 2015, 16:64
  • Network hierarchy

    A metric is devised for determining and measuring network hierarchy and then applied to the phosphorylome and regulome networks

    Genome Biology 2015, 16:63
  • Host-microbiome transcriptomic interactions

    Analysis of mouse ileal and colonic tip, and crypt epithelial fractions finds that microbiota affect host gene expression in specific niches

    Genome Biology 2015, 16:62
  • Germline epigenome reprogramming

    Epigenetic effects of endocrine disrupting chemicals in germ cells are corrected by germline reprogramming events in the next generation

    Genome Biology 2015, 16:59
  • Single-cell exome sequencing

    A new method for single nucleus exome sequencing with low allelic dropout rates and FPRs results in excellent variant detection

    Genome Biology 2015, 16:55
  • RNA defects in RRMS

    Relapsing-remitting multiple sclerosis is associated with widespread defects in RNA processing and splicing

    Genome Biology 2015, 16:58
  • Genome-to-phenome with FAANG

    The FAANG Consortium introduces a new project to produce comprehensive maps of functional elements in the genomes of domesticated animal species.

    Genome Biology 2015, 16:57
  • MUSiCC

    MUSiCC is a method for normalizing metagenomic data, based on the abundances of a panel of universal single-copy genes

    Genome Biology 2015, 16:53
  • MicrobeCensus

    MicrobeCensus is a method for estimating average genome size from shotgun metagenomic data based on single-copy gene families

    Genome Biology 2015, 16:51
  • Ensembl Regulatory Build

    The Ensembl Regulatory Build is a browsable collection of putative regulatory elements inferred from ENCODE ChIP-seq data

    Genome Biology 2015, 16:56
3D Organisation of the nucleus
Cancer Progression
Genome Biology Single Cell
Genomics of infectious diseases: special issue
Avian Genomes collection
Model-based Analysis of Genome-wide CRISPR/Cas9 Knockout (MAGeCK)

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ISSN: 1465-6906