Biology for the post-genomic era

Genome Biology publishes research articles, new methods and software tools, in addition to reviews and opinions, from the full spectrum of biology, including molecular, cellular, organism or population biology studied from a genomic perspective, as well as sequence analysis, bioinformatics, proteomics, comparative biology and evolution.


  • Clare Garvey PhD, Genome Biology


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  • Tumor heterogeneity

    Charles Swanton and colleagues review the ins and outs of intratumor heterogeneity and how does it affect personalized medicine

    Genome Biology 2014, 15:453
  • N-of-1 studies

    Obi Griffith, Andrew Su and colleagues discuss the challenges of combining the genomic knowledge and N-of-1 studies to improve personalized medicine

    Genome Biology 2014, 15:438
  • Gastric cancer N-of-1

    David Adams and colleagues discuss the elegant approach for the cancer evolution studies, combining sequencing with the clever choice of cancer models

    Genome Biology 2014, 15:444
  • Kidney cancer evolution

    An analysis of sporadic renal cell carcinoma case reveals new insights about evolutionary principles affecting tumor development

    Genome Biology 2014, 15:433
  • Gastric cancer evolution

    Tumor evolution in a diffuse gastric cancer patient and cancer modeling reveals the metastatic contribution of Tgfbr2 loss-of-function

    Genome Biology 2014, 15:428
  • SubcloneSeeker

    A new statistical framework for the reconstruction of tumor clone structure

    Genome Biology 2014, 15:443

    A new method for the analysis of the clonal hierarchy of somatic genomic aberrations from WGS and WES data

    Genome Biology 2014, 15:439
  • Hepatocellular carcinoma genomics

    Whole genome and transcriptome sequencing of matched tumor-normal tissue for hepatocellular carcinoma cases reveals low frequency mutations associated with the disease

    Genome Biology 2014, 15:436
  • Prostate cancer heterogeneity

    An analysis of transcriptome heterogeneity in high-risk prostate cancer identifies a novel rare molecular subtype

    Genome Biology 2014, 15:426
  • Breast cancer methylation

    An analysis of a breast cancer cohort reveals large methylation changes and demonstrates a prognostic value of a DNA methylation signature

    Genome Biology 2014, 15:435
  • Wilms tumor biomarkers

    Methylome analysis of Wilms tumor identifies differentially methylated biomarker regions that can be detected in cell-free circulating DNA

    Genome Biology 2014, 15:434

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Latest issue

Genome Biology Volume 15 Issue 7

The complete issue of Genome Biology Volume 15 Issue 7 is now available.

Free webinar on plant genomics:

Breeding opportunities out of challenges, broadcast live 18th April 2013 sponsored by Affymetrix. A free to view panel discussion between Clare Garvey, Editor – Genome Biology, BioMed Central, Etienne Paux, INRA and Doreen Ware, USDA ARS, Adjunct Associate Professor, Cold Spring Harbor Laboratory.

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ISSN: 1465-6906