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Volume 8 Suppl 1
Transposons in vertebrate functional genomicsAlso on BioMed Central
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The editor's selection of refereed research articles published recently in BMC Genomics and BMC Bioinformatics
Resequencing genomes improves data quality
Errors in microbial genome sequences are not restricted to point mutations and may also consist of large-scale rearrangements, such as insertions, which should be rectified so that these data can be of continuing use.
BMC Genomics 2008, 9:138

Mind the GAPscreener
PubMed abstracts can now be effectively screened for articles related to human genetic association studies and genome epidemiology using GAPscreener, a free java-based tool.
BMC Bioinformatics 2008, 9:205

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Adsumo

 Welcome to Genome Biology
  Biology for the post-genomic era.

Research    
The Stenotrophomonas maltophilia genome
Crossman LC, Gould VC, Dow JM, Vernikos GS, Okazaki A, Sebaihia M, Saunders D, Arrowsmith C, Carver T, Peters N, et al. / 17 April 2008

The complete Stenotrophomonas maltophilia genome sequence suggests that it can act as a reservoir of antibiotic resistance determinants.

Review   
The AAA+ superfamily of functionally diverse proteins
Snider J, Thibault G, Houry WA / 30 April 2008

The AAA+ superfamily is a large superfamily of ATPases that are characterized by a conserved catalytic module, the AAA+ module. Members are involved in an astonishing range of different cellular processes.

Research    
The Podospora anserina genome sequence
Espagne E, Lespinet O, Malagnac F, Da Silva C, Jaillon O, Porcel BM, Couloux A, Aury JM, Ségurens B, Poulain J, et al. / 06 May 2008

A 10X draft sequence of Podospora anserina genome shows highly dynamic evolution since its divergence from Neurospora crassa.

Minireview   
The topless plant developmental phenotype explained!
Osmont KS, Hardtke CS / 30 April 2008

TOPLESS acts as a corepressor of auxin-mediated gene expresssion in plant development.

Research    
Measure of selective constraints
Liu J, Zhang Y, Lei X, Zhang Z / 08 April 2008

A large-scale survey using single nucleotide polymorphism data from dbSNP provides insights into the evolutionary selection constraints on human proteins of different structural and functional categories.

Review   
Genetic determinants of phenotypic diversity in humans
Rahim NG, Harismendy O, Topol EJ, Frazer KA / 24 April 2008

New techniques are enabling the identification of genetic variants underlying complex diseases and phenotypic traits.

Research    
Bacterial transcript and metabolite evolution
Vijayendran C, Barsch A, Friehs K, Niehaus K, Becker A, Flaschel E / 10 April 2008

Transcript and metabolite abundance changes were analyzed in evolved and ancestor strains of Escherichia coli in three different evolutionary conditions

Method    
Detecting intracellular proteolysis
Ketteler R, Sun Z, Kovacs KF, He WW, Seed B / 03 April 2008

A new system based on non-conventional secretion of the luciferase from Gaussia princeps (GLUC) can be used to detect intracellular proteolysis in vivo.

The complete issue of Genome Biology Volume 9 Issue 4 is now available.

Comment   
Petsko GA / 30 April 2008
Meeting report   
Gorringe KL, Campbell IG / 07 May 2008
Research    
Bloomfield G, Tanaka Y, Skelton J, Ivens A, Kay RR / 22 April 2008
Research    
Haussmann IU, White K, Soller M / 17 April 2008
Minireview   
Pietras EM, Cheng G / 25 April 2008
Meeting report   
Robatzek S, Saijo Y / 09 April 2008
Review    
Hammann C, Westhof E / 30 April 2007

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