Biology for the post-genomic era
Genome Biology publishes research articles, new methods and software tools, in addition to reviews and opinions, from the full spectrum of biology, including molecular, cellular, organism or population biology studied from a genomic perspective, as well as sequence analysis, bioinformatics, proteomics, comparative biology and evolution.
Articles
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Genome Biology 2012, 13:R39Polar alga genome
The first genome of a polar eukaryotic microorganism, an alga called Coccomyxa subellipsoidea C-169, reveals universal strategies for cold adaptation
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Genome Biology 2012, 13:R38Entamoeba histolytica diversity
Ten strains of Entamoeba histolytica are sequenced. Low levels of genetic diversity are found, and evidence for sexual reproduction is uncovered
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Genome Biology 2012, 13:R37Multi-omics systems analysis
An analysis of multi-omics data and the generation of a genome-scale metabolic network to determine the phenotypic characteristics of E. coli
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Genome Biology 2012, 13:R36Cell cycle control
A screen for regulators of the G2/M transition in fission yeast reveals novel regulators of cell cycle control
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Genome Biology 2012, 13:R35NMD-dependent splicing
An extensive in vivo analysis of how nonsense mediated mRNA decay regulates alternative splicing in two mouse tissues
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Genome Biology 2012, 13:156Cancer epigenomes
A Research Highlight on the role of variant epigenetics in establishing an enhancer element-mediated oncogenic transcriptional program
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Genome Biology 2012, 13:R34Detecting low-level mutations
A method is presented for differentiating mutations present at low level in a sample from sequencing errors
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Genome Biology 2012, 13:157Brain transcriptomes
Philipp Khaitovich highlights research by Allan Jones and colleagues that assesses regional gene expression in the human brain neocortex
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Featured free review
From RNA-seq reads to differential expression results
Many methods and tools are available for preprocessing high-throughput RNA sequencing data and detecting differential expression.
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Latest issue
The complete issue of Genome Biology Volume 13 Issue 4 is now available.
2012 special issue Epigenomics
Following on from our highly successful special issue on exome sequencing in 2011, we are now inviting submissions to the 2012 special issue which will focus on epigenomics.
For more information, see here.
Beyond the Genome 2012
The 3rd annual Beyond the Genome conference takes place in Harvard Medical School, Boston from 27-29 September 2012.
Keynote speakers announced:
Richard Gibbs, Baylor College of Medicine, USA
Stuart Schreiber, Broad Institute of Harvard and MIT, USA
Genome Biology podcast
To coincide with September's special issue, we talk with Jim Lupski, Jay Shendure, Elaine Mardis and Joris Veltman about the challenges of identifying disease genes using exome sequencing and whole genome sequencing.
Download MP3 file (Size: 35.8MB)
Twitter updates
- The first polar eukaryote genome shows evidence of convergent evolution w cold climate prokaryotes http://t.co/bdem12me #genomics #coldomics 4:12 PM May 25th, 2012
- Welcome to the "mysterious world of Noncodarnia": John Rinn & colleagues review the Keystone ncRNA meeting http://t.co/7A9seITE #genomics 2:35 PM May 25th, 2012
- @neilhall_uk and colleagues dissect the genetic diversity of the human pathogen Entamoeba histolytica http://t.co/ryXAlvO7 #genomics 1:59 PM May 25th, 2012
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