Biology for the post-genomic era
Genome Biology publishes research articles, new methods and software tools, in addition to reviews and opinions, from the full spectrum of biology, including molecular, cellular, organism or population biology studied from a genomic perspective, as well as sequence analysis, bioinformatics, proteomics, comparative biology and evolution.
Editor
- Clare Garvey PhD, Genome Biology
Editorial Board | Editorial Team | Instructions for authors | FAQ
Articles
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Genome Biology 2013, 14:R112Condensin binding
A genome-wide analysis of condensin binding in the model organism Caenorhabditis elegans
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Genome Biology 2013, 14:R111DNA replication timing
Genes transcribed during S-phase are found to replicate early in human, budding yeast and fission yeast
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Genome Biology 2013, 14:R109Small RNA cloning
An efficient sRNA cloning method from Rui Yi's lab overcomes ligation biases and enables accurate quantification over a wide dynamic range
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Genome Biology 2013, 14:R108Kidney disease epigenetics
The enhancers of genes involved in fibrosis exhibit DNA methylation in chronically diseased kidneys, with correlated changes in gene expression
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Genome Biology 2013, 14:214Complex trait interpretation
Nigel Collier reviews how algorithmic advances are set to enhance the description of complex traits through high-throughput phenotype analysis
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Genome Biology 2013, 14:213Neurexins
A Protein Family Review by Markus Missler and colleagues considers the role of neurexins in synaptic function and, consequently, neurological conditions
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Genome Biology 2013, 14:133Watch your speed!
David Price proposes that 7SK snRNA is a key barrier to runaway transcription - in contrast to the inept engineer Casey Jones
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Genome Biology 2013, 14:132PINTing for p53
Ramin Sheikhattar discusses new findings, published in Genome Biology, about a novel lncRNA ('PINT'), p53 and cancer
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Featured free review
Daniel Geschwind and Jamee Berg review the genes associated with autism spectrum disorders: how might their functions relate to one another?
Latest articles from Genome Medicine
Method
A simple consensus approach improves somatic mutation prediction accuracy
Genome Medicine 2013, 5:90
Method
A SNP profiling panel for sample tracking in whole-exome sequencing studies
Genome Medicine 2013, 5:89
Research highlight
Cancer mutation signatures, DNA damage mechanisms, and potential clinical implications
Genome Medicine 2013, 5:87
Research
Genome Medicine 2013, 5:86
Latest issue
The complete issue of Genome Biology Volume 14 Issue 9 is now available.
Soapbox
A simple consensus approach improves somatic mutation prediction accuracy
Three somatic mutation detection algorithms, MuTect, JointSNVMix2 and SomaticSniper, are validated against Sanger sequencing and a consensus of all three found to be the most accurate.
A SNP profiling panel for sample tracking in whole-exome sequencing studies
As more samples are submitted for whole-exome sequencing, the challenge is to accurately track them through the process. A SNP profiling panel can identify samples in the clinic and the lab.
Cancer mutation signatures, DNA damage mechanisms, and potential clinical implications
Reuben Harris discusses how mutational signatures could be diagnostic, prognostic, and therapeutic biomarkers, highlighting a recent study that found several signatures across different cancer types.
Serum proteomic profiling in healthy subjects reveals that increased levels of several acute phase and other immune proteins are present in those who develop signs of acetaminophen-induced liver injury.
Free webinar on plant genomics:
Breeding opportunities out of challenges, broadcast live 18th April 2013 sponsored by Affymetrix. A free to view panel discussion between Clare Garvey, Editor – Genome Biology, BioMed Central, Etienne Paux, INRA and Doreen Ware, USDA ARS, Adjunct Associate Professor, Cold Spring Harbor Laboratory.
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