Phylogenetic variation and polymorphism at the Toll-like receptor 4 locus (TLR4)
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* Corresponding author: Bruce Beutler beutler@howie.swmed.edu
Genome Biology 2000, 1:research002-research002.10 doi:10.1186/gb-2000-1-1-research002
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Protein family review
Toll-like receptors: a family of pattern-recognition receptors in mammals Myriam A Armant, Matthew J Fenton Genome Biology 2002, 3:reviews3011-reviews3011.6 (29 July 2002) Toll-like receptors are a family of pattern-recognition receptors in mammals that can discriminate between chemically diverse classes of microbial products, including bacterial cell-wall components, and that can elicit pathogen-specific cellular immune responses. Toll-like receptors share characteristic features with the interleukin-1 and interleukin-18 cytokine receptors and these receptor classes activate similar signal-transduction pathways. |
