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What initiates actin polymerization?

Anne Ridley

Author Affiliations

Ludwig Institute for Cancer Research, Royal Free and University College Medical School Branch, 91 Riding House Street, London W1P 8BT, UK

Genome Biology 2000, 1:reviews102-reviews102.4  doi:10.1186/gb-2000-1-1-reviews102

Published: 27 April 2000

Abstract

For those working on the actin cytoskeleton, a major theme of the 39th annual meeting of the American Society for Cell Biology [http://www.faseb.org/ascb/meetings/am99/main99mtg.htm webcite] (Washington DC, December 11-15, 1999) was the elucidation of how actin polymerization is initiated. The emphasis was on the regulation and localization of the Arp2/3 complex, which over the last two years has been shown to stimulate actin nucleation, and on the identification of additional proteins that interact with actin and Arp2/3 in a variety of organisms.