Cooperative action of polymerizing actin filaments. Calculations of the force exerted by actin filaments on a nucleating bead show its dependence on the dissociation rate of actin monomers. At low dissociation rates, the bead experiences a very small force and remains trapped in its cloud of cross-linked actin. At an optimal value of dissociation rate, the forces are sufficient to drive the bead through its actin cloud and to rocket through the cytoplasm (data from ).
Bray Genome Biology 2000 1:reviews108.1-reviews108.3 doi:10.1186/gb-2000-1-1-reviews108