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Eat the dead

William Wells

Author Affiliations

Genome Biology 2000, 1:spotlight-20000508-03  doi:10.1186/gb-spotlight-20000508-03


The electronic version of this article is the complete one and can be found online at:


Published:8 May 2000

© 2000 BioMed Central Ltd

Research news

Apoptosis eliminates the asymmetry of plasma membrane phospholipids and exposes phosphatidylserine on the outside of cells. Fadok et al. report in the May 4 Nature that they have found a phagocyte protein that recognizes the phosphatidylserine (Nature 2000, 405:85-90). Addition of the receptor to lymphocytes allows the cells to engulf apoptotic cells. Engagement of the receptor on macrophages induces the production of anti-inflammatory TGF-b consistent with the absence of inflammation during apoptosis.

References

  1. Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages.

    PubMed Abstract OpenURL

  2. [http://www.nature.com/nature/] webcite

    Nature magazine's homepage