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A lot of bloody genes

William Wells

Author Affiliations

Genome Biology 2000, 1:spotlight-20000607-01  doi:10.1186/gb-spotlight-20000607-01


The electronic version of this article is the complete one and can be found online at:


Published:7 June 2000

© 2000 BioMed Central Ltd

Research news

In the 2 June Science, Phillips et al. announce the creation of the Stem Cell Database (SCDb), an annotated collection of genes expressed in hematopoietic stem cells (Science 2000, 288:1635-1640). Most of the data are based on the sequencing of 5735 clones from a subtracted stem cell library, representing at least half of the library's complexity. The SCDb reveals clues to stem cell biology, such as the coincidence of semaphorins and their ligands, suggesting that these molecules are important for stem cell adhesion and homing. But, perhaps most importantly, the list of genes will serve as the basis for stem cell microarrays that can be used to analyze changes in regulatory networks as stem cells renew and differentiate.

References

  1. [http://www.sciencemag.org/] webcite

    Science Magazine

  2. [http://stemcell.princeton.edu/] webcite

    Princeton stem cell database