Table 3

Human chromosome 21 centromere-proximal genes

(a) Genes proximal to APP
(b) Genes from APP to SOD1

Gene
Classification
Gene
Classification

Pred 65
Zn finger
APP

Pred 3
Keratinocyte growth factor
Pred24

Pred 4
Similar to KIAA1074
ADAMTS1
Metalloproteinase
orf15
EST
ADAMTS5
Metalloproteinase
Pred5
Lipase
Pred25
Exon
RBM11
RNA binding
Pred26
Exon
Pred6
Exon
orf23
EST
STCH
Stress protein
Pred27
Exon
SAMSN-1
Similar to KIAA0790
Pred28
Methyltransferase
NRIP1
Nuclear factor
ZNF294
Zinc finger
USP28
Ubiquitin protease
orf6
EST
orf34
EST
USP16
Ubiquitin protease
orf35
EST
CCT8
T-complex subunit
orf36
EST
orf7
Exon
orf37
EST
Bach1
Transcription factor
CXADR
Viral receptor
orf12
EST
BTG3
Cell cycle control
orf8
EST
YG81
CDNA
GRIK1
Glutamate receptor
orf39
EST
Orf41
EST
Pred12
Mannose receptor
orf9
EST
PRSS7
Enterokinase
CLDN17
Claudin receptor
orf40
EST
CLDN8
Claudin receptor
NCAM2
Neural adhesion
Pred29
Exon
Pred15
Exon
Pred30
Exon
Pred16
EST
TIAM1
Lymphoma metastasis
orf53
EST
Pred 31
Exon
orf42
EST
SOD1

Pred21
EST


Red22
tRNA synthetase


orf43
Junction adhesion


ATP5A
ATPase factor


GABPA
Transcription factor



(a) Mouse homologs possibly disomic in both Ts65Dn and Ts1Cje. (b) Mouse homologs expected to be trisomic in Ts65Dn but disomic in Ts1Cje.

Gardiner and Davisson Genome Biology 2000 1:reviews0002.1   doi:10.1186/gb-2000-1-2-reviews0002