A molecular portrait of the response to unfolded proteins

Ardythe A McCracken¹ and Jeffrey L Brodsky²

¹Department of Biology, University of Nevada, Reno, NV 89557, USA

²Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA

author email corresponding author email

Genome Biology 2000, 1:reviews1013.1-1013.3doi:10.1186/gb-2000-1-2-reviews1013


Published:	4 August 2000

Subject areas: Cell biology, Molecular biology, Genome studies, Biochemistry and structural biology

Abstract

Using DNA microarrays, 381 genes have been found to be induced in response to unfolded proteins. The identity of the previously characterized 208 of these, and further experiments, have revealed new details on the scope of the unfolded protein response and its connection to the degradation of proteins at the endoplasmic reticulum.