Table 3

Human chromosome 21 centromere-proximal genes

(a) Genes proximal to APP

(b) Genes from APP to SOD1


Gene

Classification

Gene

Classification


Pred 65

Zn finger

APP

Pred 3

Keratinocyte growth factor

Pred24

Pred 4

Similar to KIAA1074

ADAMTS1

Metalloproteinase

orf15

EST

ADAMTS5

Metalloproteinase

Pred5

Lipase

Pred25

Exon

RBM11

RNA binding

Pred26

Exon

Pred6

Exon

orf23

EST

STCH

Stress protein

Pred27

Exon

SAMSN-1

Similar to KIAA0790

Pred28

Methyltransferase

NRIP1

Nuclear factor

ZNF294

Zinc finger

USP28

Ubiquitin protease

orf6

EST

orf34

EST

USP16

Ubiquitin protease

orf35

EST

CCT8

T-complex subunit

orf36

EST

orf7

Exon

orf37

EST

Bach1

Transcription factor

CXADR

Viral receptor

orf12

EST

BTG3

Cell cycle control

orf8

EST

YG81

CDNA

GRIK1

Glutamate receptor

orf39

EST

Orf41

EST

Pred12

Mannose receptor

orf9

EST

PRSS7

Enterokinase

CLDN17

Claudin receptor

orf40

EST

CLDN8

Claudin receptor

NCAM2

Neural adhesion

Pred29

Exon

Pred15

Exon

Pred30

Exon

Pred16

EST

TIAM1

Lymphoma metastasis

orf53

EST

Pred 31

Exon

orf42

EST

SOD1

Pred21

EST

Red22

tRNA synthetase

orf43

Junction adhesion

ATP5A

ATPase factor

GABPA

Transcription factor


(a) Mouse homologs possibly disomic in both Ts65Dn and Ts1Cje. (b) Mouse homologs expected to be trisomic in Ts65Dn but disomic in Ts1Cje.

Gardiner and Davisson Genome Biology 2000 1:reviews0002.1-reviews0002.9   doi:10.1186/gb-2000-1-2-reviews0002