Table 2

Host and pathogen DNA array studies

Cell type

Pathogen

Array

Genes

Array type and support

Experiment

Reference


Human foreskin fibroblasts

Human cytomegalovirus

Pathogen

207 genes

Oligonucleotides on glass slides

Virus gene expression during lytic replication

[5]

Human B-cell*

Human herpesvirus 8

Pathogen

120 genes

PCR products on nylon

Virus gene expression during latent and lytic replication

||

Human T-cell

Human immuno-deficiency virus type 1

Host

1,500 genes

PCR products on glass slides

Host gene expression during 72 hours of virus infection

[7]

Normal human keratinocytes

Human papillomavirus type 31

Host

7,075 genes

PCR products on glass slides

Host gene expression following transfection of the viral genome

[8]

Human foreskin fibroblasts

Human cytomegalovirus

Host

6,600 genes

Affymetrix microarrays

Host gene expression during 24 hours of virus infection

[6]

Human colorectal and colon§ epithelial cells

Salmonella dublin

Host

4,300 genes

PCR products on nylon

Host gene expression during 20 hours of bacterial infection

[10]

Human monocytes

Listeria monocytogenes

Host

6,800 genes, 18,367 genes, 588 genes

Affymetrix microarrays, PCR products on nylon

Host gene expression during 2 hours of bacterial infection

[9]


*Primary effusion lymphoma cell line BC-3; T-cell lymphoma cell line CEMCCRF; HT-29 cells; §T84 cells; THP- I cells. ||R.G. Jenner, et al., unpublished observations.

Kellam Genome Biology 2000 1:reviews1009.1-reviews1009.4   doi:10.1186/gb-2000-1-2-reviews1009