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A molecular portrait of the response to unfolded proteins

Ardythe A McCracken1* and Jeffrey L Brodsky2

Author Affiliations

1 Department of Biology, University of Nevada, Reno, NV 89557, USA

2 Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA

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Genome Biology 2000, 1:reviews1013-reviews1013.3  doi:10.1186/gb-2000-1-2-reviews1013

Published: 4 August 2000

Abstract

Using DNA microarrays, 381 genes have been found to be induced in response to unfolded proteins. The identity of the previously characterized 208 of these, and further experiments, have revealed new details on the scope of the unfolded protein response and its connection to the degradation of proteins at the endoplasmic reticulum.