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Hopping along DNA

William Wells

Author Affiliations

Genome Biology 2000, 1:spotlight-20000713-02  doi:10.1186/gb-spotlight-20000713-02

The electronic version of this article is the complete one and can be found online at:


Published:13 July 2000

© 2000 BioMed Central Ltd

Research news

Oxidative damage yields isolated electrons and their corresponding 'holes' that can migrate along DNA. In the 6 July Nature Lewis et al. determine rate constants of ~5x107 s-1 and 5x106 s-1, respectively, for forward and return hole transport from a single guanine base to a double guanine base across a single adenine (Nature 2000, 406:51-53). These rates mean that electrons do not linger long enough to participate in strand-cleavage reactions. But the electrons move too slowly to avoid charge recombination, so DNA cannot act as a useful molecular wire.

References

  1. Distance-dependent electron transfer in DNA hairpins.

    PubMed Abstract | Publisher Full Text OpenURL

  2. [http://www.nature.com/nature/] webcite

    Nature