Email updates

Keep up to date with the latest news and content from Genome Biology and BioMed Central.

Research news

Breast cancer linked to chromatin remodeling

William Wells

Genome Biology 2000, 1:spotlight-20000731-01  doi:10.1186/gb-spotlight-20000731-01

The electronic version of this article is the complete one and can be found online at:


Published:31 July 2000

© 2000 BioMed Central Ltd

Research news

BRCA1 is a tumor-suppressor gene linked to familial breast and ovarian cancers. In the July 21 Cell, Bochar et al. find that the predominant BRCA1-containing complex in human cells is the SWI/SNF-related chromatin remodeling complex (Cell 2000, 102:257-265). This may explain the multitude of properties that have been ascribed to BRCA1, including effects on transcription, DNA repair, and cell-cycle checkpoints. Mutations in SNF5, another subunit of the SWI/SNF complex, have been shown to result in aggressive pediatric cancer, and a close inspection of other SWI/SNF proteins and genes may turn up other cancer culprits.

References

  1. A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1.

    PubMed Abstract OpenURL

  2. [http://www.cell.com/] webcite

    Cell

  3. Truncating mutations of hSNF5/INI1 in aggressive paediatric cancer.

    PubMed Abstract | Publisher Full Text OpenURL