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A baffling protein

William Wells

Genome Biology 2000, 1:spotlight-20000731-02  doi:10.1186/gb-spotlight-20000731-02

The electronic version of this article is the complete one and can be found online at:


Published:31 July 2000

© 2000 BioMed Central Ltd

Research news

Barrier-to-autointegration factor (BAF) is a cellular protein that prevents destructive insertions of retroviruses into their own genomes. In the August 1 Proceedings of the National Academy of Sciences, Zheng et al. propose that BAF's usual function may be in chromosome condensation (Proc. Natl. Acad. Sci. USA 2000, 97:8997-9002). BAF added to DNA forms primarily a dodecamer that binds five or six DNA molecules. The processes of DNA binding and formation of the higher-order BAF multimer are coupled. Interference with BAF function by RNAi in worm embryos results in abnormal chromosome segregation, with chromatin trailing between segregating chromosomes. Thus BAF may function in chromosome organization or condensation.

References

  1. A previously unidentified host protein protects retroviral DNA from autointegration.

    PubMed Abstract | Publisher Full Text | PubMed Central Full Text OpenURL

  2. [http://www.pnas.org/] webcite

    Proceedings of the National Academy of Sciences