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A polymerase for sister chromatid cohesion

William Wells

Genome Biology 2000, 1:spotlight-20000810-01  doi:10.1186/gb-spotlight-20000810-01

The electronic version of this article is the complete one and can be found online at:


Published:10 August 2000

© 2000 BioMed Central Ltd

Research news

Cohesins, the proteins that are thought to anchor sister chromatids to one another before anaphase, must be present during DNA replication if cohesion is to be established. In the 4 August Science Wang et al. provide a possible link between replication and cohesion (Science 2000, 289:774-779). They describe an essential DNA polymerase in budding yeast that both has polymerase activity and is required for sister chromatid cohesion. They suggest that the replication fork may switch to this polymerase at special cohesion sites, where the polymerase then recruits cohesins.

References

  1. Splitting the chromosome: cutting the ties that bind sister chromatids.

    PubMed Abstract | Publisher Full Text OpenURL

  2. Cohesion between sister chromatids must be established during DNA replication.

    PubMed Abstract | Publisher Full Text OpenURL

  3. [http://www.sciencemag.org/] webcite

    Science Magazine