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Engineering translocations

Jonathan B Weitzman

Author Affiliations

Genome Biology 2000, 1:spotlight-20000830-01  doi:10.1186/gb-spotlight-20000830-01

Published: 30 August 2000

The Cre-lox system for targeted recombination has been used successfully to create designer chromosomal translocations in mice that resemble those found in human tumors.