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Chromodomains bind RNA

William Wells

Genome Biology 2000, 1:spotlight-20000927-01  doi:10.1186/gb-spotlight-20000927-01

The electronic version of this article is the complete one and can be found online at:


Published:27 September 2000

© 2000 BioMed Central Ltd

Research news

Male flies compensate for having a single X chromosome by doubling the single X chromosome's level of expression. This increase is mediated by MOF, a histone H4 acetyltransferase. MOF, along with other proteins and an RNA called roX2, binds to the male X chromosome. In the 21 September Nature Akhtar et al. find that MOF and another dosage compensation protein called MSL-3 use their chromodomains to bind to roX2 and thus to the male X (Nature 2000, 407:405-409). Other chromodomain proteins, which function as chromatin regulators, may also have RNA-binding activity. If this is the case, non-coding RNAs may be more commonly involved in organizing regulatory complexes than has been appreciated to date.

References

  1. Dosage compensation in flies and worms: the ups and downs of X-chromosome regulation.

    PubMed Abstract | Publisher Full Text OpenURL

  2. Activation of transcription through histone H4 acetylation by MOF, an acetyltransferase essential for dosage compensation in Drosophila.

    PubMed Abstract | Publisher Full Text OpenURL

  3. The rox1 and rox2 RNAs are essential components of the compensasome, which mediates dosage compensation in Drosophila.

    PubMed Abstract | Publisher Full Text OpenURL

  4. [http://www.nature.com/nature/] webcite

    Nature