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Secret sharers in the immune system: a novel RNA editing activity links switch recombination and somatic hypermutation
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Correspondence: Nancy Maizels maizels@u.washington.edu
Departments of Immunology and Biochemistry, University of Washington Medical School, 1959 NE Pacific Street, Seattle, WA 98195-7650, USA
Genome Biology 2000, 1:reviews1025-reviews1025.3 doi:10.1186/gb-2000-1-4-reviews1025
Published: 13 October 2000Abstract
A new mechanism for regulation in the immune system has been identified: a cytidine deaminase is critical for both class switch recombination and somatic hypermutation, revealing an unanticipated link between these two processes.