Genome Biology
Volume 1
Issue 5 |
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ReviewCan sequence determine function?John A Gerlt1  and Patricia C Babbitt2 1Departments of Biochemistry and Chemistry, University of Illinois, Urbana, IL 61801, USA 2Departments of Biopharmaceutical Sciences and Pharmaceutical Chemistry, University of California, San Francisco, CA 94143, USA  author email corresponding author email
Genome Biology 2000,
1:reviews0005.1-0005.10doi:10.1186/gb-2000-1-5-reviews0005
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8 November 2000 |
Subject areas: Biochemistry and structural biology, Genome studies, Bioinformatics Abstract
The functional annotation of proteins identified in genome sequencing projects is based on similarities to homologs in the databases. As a result of the possible strategies for divergent evolution, homologous enzymes frequently do not catalyze the same reaction, and we conclude that assignment of function from sequence information alone should be viewed with some skepticism. | 
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