Table 1 |
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F-box proteins in the yeast, nematode, and human genomes |
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| Additional motifs |
S. cerevisiae |
C. elegans |
Human |
|
|
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| WD repeats |
2 |
3 |
5 |
| Cdc4 |
LIN-23 |
FBXW1 (ß-TrCP) |
|
| Met30 |
SEL-10 |
FBXW1B (ß-TrCP2/HOS) |
|
| T01E8.4 |
FBXW2 |
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| FBXW3 |
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| FBXW6* |
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| Leucine-rich |
2 |
3 |
10 |
| repeats |
Grr1 |
C02F5.7 |
FBXL1 (SKP2) |
| YOR080w |
F48E8.7 |
FBXL2 |
|
| F58E1.8 |
FBXL3A |
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| FBXL3B |
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| FBXL4 - FBXL7 |
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| FBXL9 |
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| FBXL11 |
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| FTH / DUF38 |
0 |
135† |
0 |
| PfamB 45 |
0 |
56† |
0 |
| Other/none |
7 |
129† |
21 |
| El1a |
FBXO1 (cyclin F) |
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| YNL311c |
FBXO2 (NFB42) |
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| YML088w |
FBXO3 - FBXO12* |
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| YLR368w |
FBXO20 - FBXO26* |
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| YDR219c |
FBXO29 |
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| YJL149w |
Elongin A |
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| YDR131c |
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| Total |
11 |
326 |
36 |
|
|
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The proteins in this table were obtained from the European Bioinformatics Institute InterPro Project [29] with additional entries (20 for C. elegans and 3 for humans) discovered through database analysis by ETK. *This is the first report of FBXW6, FBXO12, and FBXO26 as F-box proteins. They were identified by database search and correspond to the GenBank [31] entries FLJ11071 (accession number NM_018315.1), FLJ20188 (accession number NM_017703), and KIAA1195/muscle disease-related protein (accession number AB033021/AF204674), respectively. FBXO12 is the apparent ortholog of murine fbxo12. Missing numbers in the human FBX gene series have been given to mouse genes for which the human orthologs have not (yet) been identified. †The very large number of C. elegans proteins in these categories are listed in Additional data file 1. |
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Kipreos and Pagano Genome Biology 2000 1:reviews3002.1 doi:10.1186/gb-2000-1-5-reviews3002 |
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