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F-box proteins that function in SCF complexes |
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| F-box protein |
Organism |
Substrates |
Mutant phenotype |
|
|
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| Cdc4 |
S. cerevisiae |
Sic1 and Far1 - CDK inhibitors |
G1 cell-cycle arrest |
| Cdc6 - DNA replication factor |
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| Gcn4 - transcription factor |
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| Met30 |
S. cerevisiae |
Met4 - transcription factor |
G1 cell-cycle arrest |
| Swe1 - cell cycle kinase |
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| Grr1 |
S. cerevisiae |
Cln1 and Cln2 - G1 cyclins |
Defective glucose signaling |
| Gic2 - cytoskeleton regulator |
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| Pop1 |
S. pombe |
Rum1 - CDK inhibitor |
Polyploidy |
| Cdc18 - DNA replication factor |
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| Pop2/Sud1 |
S. pombe |
Rum1 - CDK inhibitor |
Polyploidy |
| Cdc18 - DNA replication factor |
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| Scon2* |
N. crassa |
? |
Defective sulfur response |
| SconB* |
A. nidulans |
? |
Defective sulfur response |
| TIR1 |
A. thaliana |
? |
Defective auxin response |
| COI1* |
A. thaliana |
? |
Defective jasmonite response |
| LIN-23* |
C. elegans |
? |
Hyperplasia |
| SEL-10* |
C. elegans |
LIN-12 - cell surface receptor |
Basically wild type |
| Slimb* |
D. melanogaster |
Armadillo - adhesion and signaling |
Centrosome over-replication and mutant clones induce |
| Cubitus Interruptus - transcription factor |
ectopic limbs in surrounding tissue |
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| ß-TrCP |
H. sapiens |
ß-catenin - adhesion and signaling |
|
| I?Ba - transcription inhibitor |
? |
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| CD4 - cell surface receptor (when cells are infected by HIV) |
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| ß-TrCP2/HOS |
H. sapiens |
ß-catenin - adhesion and signaling |
? |
| I?Ba - transcription inhibitor |
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| SKP2 |
H. sapiens / |
cyclin E- G1 cyclin (free, not bound by CDK2) |
Small mice with some polyploid tissues and centrosome |
| M. musculus |
p27KIP1 - CDK inhibitor |
over-replication |
|
|
*F-box proteins that have not been experimentally demonstrated to function in SCF complexes, but each are orthologs of known SCF proteins in other organisms and so are likely to function in SCF complexes. Two other plant F-box proteins, UFO and FIM, are required for flower development in Arabidopsis thaliana and Antirrhinum majus, respectively [32,33]. Although both of these F-box proteins bind to Skp1 proteins, it is unclear whether they function in SCF complexes or bind Skp1 for other purposes, as is the case for Ctf13. Additional potential substrates that have not been conclusively documented are not listed. References can be obtained from [10], with the exception of the more recent references for LIN-23 [34], centrosome over-replication in Slimb mutants [35], and the substrates Met4 [36], Gcn4 [37], cyclin E [38], and p27KIP1 [25,38,39,40]. Species included in the table are Saccharomyces cerevisiae, Schizosaccharomyces pombe, Neurospora crassa, Aspergillus nidulans, Arabidopsis thaliana, Caenorhabditis elegans, Drosophila melanogaster, Homo sapiens and Mus musculus. | |||
Kipreos and Pagano Genome Biology 2000 1:reviews3002.1 doi:10.1186/gb-2000-1-5-reviews3002 |
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