Table 2

F-box proteins that function in SCF complexes
F-box protein
 Organism
 Substrates
 Mutant phenotype
Cdc4
 S. cerevisiae
 Sic1 and Far1 - CDK inhibitors
 G1 cell-cycle arrest


Cdc6 - DNA replication factor


Gcn4 - transcription factor
Met30
 S. cerevisiae
 Met4 - transcription factor
 G1 cell-cycle arrest


Swe1 - cell cycle kinase
Grr1
 S. cerevisiae
 Cln1 and Cln2 - G1 cyclins
 Defective glucose signaling


Gic2 - cytoskeleton regulator
Pop1
 S. pombe
 Rum1 - CDK inhibitor
 Polyploidy


Cdc18 - DNA replication factor
Pop2/Sud1
 S. pombe
 Rum1 - CDK inhibitor
 Polyploidy


Cdc18 - DNA replication factor
Scon2*
 N. crassa
 ?
 Defective sulfur response
SconB*
 A. nidulans
 ?
 Defective sulfur response
TIR1
 A. thaliana
 ?
 Defective auxin response
COI1*
 A. thaliana
 ?
 Defective jasmonite response
LIN-23*
 C. elegans
 ?
 Hyperplasia
SEL-10*
 C. elegans
 LIN-12 - cell surface receptor
 Basically wild type
Slimb*
 D. melanogaster
 Armadillo - adhesion and signaling
 Centrosome over-replication and mutant clones induce


Cubitus Interruptus - transcription factor
 ectopic limbs in surrounding tissue
ß-TrCP
 H. sapiens
 ß-catenin - adhesion and signaling


I?Ba - transcription inhibitor
 ?


CD4 - cell surface receptor (when cells are infected by HIV)
ß-TrCP2/HOS
 H. sapiens
 ß-catenin - adhesion and signaling
 ?


I?Ba - transcription inhibitor
SKP2
 H. sapiens /
 cyclin E- G1 cyclin (free, not bound by CDK2)
 Small mice with some polyploid tissues and centrosome

M. musculus
 p27KIP1 - CDK inhibitor
 over-replication

*F-box proteins that have not been experimentally demonstrated to function in SCF complexes, but each are orthologs of known SCF proteins in other organisms and so are likely to function in SCF complexes. Two other plant F-box proteins, UFO and FIM, are required for flower development in Arabidopsis thaliana and Antirrhinum majus, respectively [32,33]. Although both of these F-box proteins bind to Skp1 proteins, it is unclear whether they function in SCF complexes or bind Skp1 for other purposes, as is the case for Ctf13. Additional potential substrates that have not been conclusively documented are not listed. References can be obtained from [10], with the exception of the more recent references for LIN-23 [34], centrosome over-replication in Slimb mutants [35], and the substrates Met4 [36], Gcn4 [37], cyclin E [38], and p27KIP1 [25,38,39,40]. Species included in the table are Saccharomyces cerevisiae, Schizosaccharomyces pombe, Neurospora crassa, Aspergillus nidulans, Arabidopsis thaliana, Caenorhabditis elegans, Drosophila melanogaster, Homo sapiens and Mus musculus.

Kipreos and Pagano Genome Biology 2000 1:reviews3002.1   doi:10.1186/gb-2000-1-5-reviews3002