Genome Biology

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Towards understanding the first genome sequence of a crenarchaeon by genome annotation using clusters of orthologous groups of proteins (COGs)

Darren A Natale, Uma T Shankavaram, Michael Y Galperin, Yuri I Wolf, L Aravind and Eugene V Koonin*

Genome Biology 2000, 1:research0009-research0009.19 doi:10.1186/gb-2000-1-5-research0009

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Research article   Open Access

Insertion sequence content reflects genome plasticity in strains of the root nodule actinobacterium Frankia

Derek M Bickhart, Johann P Gogarten, Pascal Lapierre, Louis S Tisa, Philippe Normand, David R Benson BMC Genomics 2009, 10:468 (12 October 2009)

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A comprehensive evolutionary classification of proteins encoded in complete eukaryotic genomes

Eugene V Koonin, Natalie D Fedorova, John D Jackson, Aviva R Jacobs, Dmitri M Krylov, Kira S Makarova, Raja Mazumder, Sergei L Mekhedov, Anastasia N Nikolskaya, B Rao, Igor B Rogozin, Sergei Smirnov, Alexander V Sorokin, Alexander V Sverdlov, Sona Vasudevan, Yuri I Wolf, Jodie J Yin, Darren A Natale Genome Biology 2004, 5:R7 (15 January 2004)

We examined functional and evolutionary patterns in the recently constructed set of 5,873 clusters of predicted orthologs from seven eukaryotic genomes. The analysis reveals a conserved core of largely essential eukaryotic genes as well as major diversification and innovation associated with evolution of eukaryotic genomes.

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The COG database: an updated version includes eukaryotes

Roman L Tatusov, Natalie D Fedorova, John D Jackson, Aviva R Jacobs, Boris Kiryutin, Eugene V Koonin, Dmitri M Krylov, Raja Mazumder, Sergei L Mekhedov, Anastasia N Nikolskaya, B Sridhar Rao, Sergei Smirnov, Alexander V Sverdlov, Sona Vasudevan, Yuri I Wolf, Jodie J Yin, Darren A Natale BMC Bioinformatics 2003, 4:41 (11 September 2003)

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Comparative genomics of archaea: how much have we learned in six years, and what's next?

Kira S Makarova, Eugene V Koonin Genome Biology 2003, 4:115 (16 July 2003)

With 16 complete archaeal genomes sequenced to date, comparative genomics has revealed a conserved core of 313 genes that are represented in all sequenced archaeal genomes, plus a variable 'shell' that is prone to lineage-specific gene loss and horizontal gene exchange.

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The past, present and future of genome-wide re-annotation

Christos A Ouzounis, Peter D Karp Genome Biology 2002, 3:comment2001-comment2001.6 (31 January 2002)