Multiple RNA-protein interactions in Drosophila dosage compensation
Department of Genetics, Duke University Medical Center, Research Drive, Durham, NC 27710, USA
Genome Biology 2000, 1:reviews1030-reviews1030.5 doi:10.1186/gb-2000-1-6-reviews1030Published: 6 December 2000
From worms to humans, recognizing and modifying a specific chromosome is essential for dosage compensation, the mechanism by which equal X-linked gene expression in males and females is achieved. Recent molecular genetic and biochemical studies have provided new insights into how regulatory factors in Drosophila are recruited and assembled on the X chromosome, leading to the essential hypertranscription of its genes.