Metabolic control analysis: biological applications and insights
Department of Molecular Biology, Massachusetts General Hospital, 50 Blossom Street, Boston, MA 02114, USA
Genome Biology 2000, 1:reviews1031-reviews1031.5 doi:10.1186/gb-2000-1-6-reviews1031Published: 8 December 2000
Metabolic control analysis provides a robust mathematical and theoretical framework for describing metabolic and signaling pathways and networks, and for quantifying the controls over these processes. Its application has already shed light on some of the principles underlying the regulation of metabolic pathways, and it is well suited to the analysis of the types of data emerging from genomic studies.