Table 1

Summary of the enzyme activities of the nitrilase superfamily

Nitrilase branch
Nitrilase
Amidase
Reverse amidase
Carbamylase
Protein substrate







R-CN






1 - Nitrilase
Yes





2 - Aliphatic amidase

Yes




3 - Amino-terminal amidase

Yes



Yes
4 - Biotinidase

Yes
Yes


Sometimes
5 -β-Ureidopropionase

Yes


Yes

6 - Carbamylase Yes




Yes

7 - Prokaryote NAD synthetase

Predicted




8 - Eukaryote NAD synthetase

Predicted




9 - Apolipoprotein N-acyltransferase


Yes
Yes

Yes
10 -Nit and Nitfhit






11 -NB11






12 -NB12





Predicted
13 -Nonfused outliers







Pace and Brenner Genome Biology 2001 2:reviews0001.1   doi:10.1186/gb-2001-2-1-reviews0001