Genomic-scale measurement of mRNA turnover and the mechanisms of action of the anti-cancer drug flavopiridol

Lloyd T Lam¹, Oxana K Pickeral¹, Amy C Peng², Andreas Rosenwald¹, Elaine M Hurt¹, Jena M Giltnane¹, Lauren M Averett¹, Hong Zhao¹, R Eric Davis¹, Mohan Sathyamoorthy¹, Larry M Wahl³, Eric D Harris⁴, Judy A Mikovits⁴, Anne P Monks⁴, Melinda G Hollingshead⁴, Edward A Sausville⁴ and Louis M Staudt¹

¹Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA

²The EMMES Corporation, 401 N Washington Street, Suite 700, Rockville, MD 20850, USA

³National Institute for Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA

⁴Developmental Therapeutics Program, DTP Clinical Trials Unit, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, MD 20892, USA