Genome Biology

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Genomic-scale measurement of mRNA turnover and the mechanisms of action of the anti-cancer drug flavopiridol

Lloyd T Lam1, Oxana K Pickeral1, Amy C Peng2, Andreas Rosenwald1, Elaine M Hurt1, Jena M Giltnane1, Lauren M Averett1, Hong Zhao1, R Eric Davis1, Mohan Sathyamoorthy1, Larry M Wahl3, Eric D Harris4, Judy A Mikovits4, Anne P Monks4, Melinda G Hollingshead4, Edward A Sausville4 and Louis M Staudt1*

Author Affiliations

1 Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA

2 The EMMES Corporation, 401 N Washington Street, Suite 700, Rockville, MD 20850, USA

3 National Institute for Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA

4 Developmental Therapeutics Program, DTP Clinical Trials Unit, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, MD 20892, USA

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Genome Biology 2001, 2:research0041-research0041.11 doi:10.1186/gb-2001-2-10-research0041

Published: 13 September 2001

Additional files

Additional data file 1:

Flavopiridol titration

Format: CSV Size: 28KB Download file

Open Data

Additional data file 2:

Cdk inhibitors

Format: CSV Size: 38KB Download file

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Additional data file 3:

Flavopiridol, actinomycin D and DRB

Format: CSV Size: 102KB Download file

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Additional data file 4:

Half-lives of well-measured genes

Format: CSV Size: 198KB Download file

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Additional data file 5:

Proliferation genes

Format: CSV Size: 4KB Download file

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Additional data file 6:

Anti-apoptotic genes

Format: CSV Size: 1KB Download file

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Additional data file 7:

Induced genes in OCI -Ly3 cells

Format: CSV Size: 8KB Download file

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Additional data file 8:

Highly induced genes in PBMC

Format: CSV Size: 4KB Download file

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Additional data file 9:

Highly induced chemokines, cytokines and their receptors

Format: CSV Size: 2KB Download file

Open Data