Functional genomics and metal metabolism
Department of Nutritional Sciences, University of Missouri-Columbia, Columbia, MO 65211, USA
Genome Biology 2001, 2:reviews1028-reviews1028.3 doi:10.1186/gb-2001-2-10-reviews1028Published: 14 September 2001
Metal ions are essential nutrients, yet they can also be toxic if they over-accumulate. Homeostatic mechanisms and detoxification systems therefore precisely control their intracellular levels and distribution. The tools of functional genomics are rapidly accelerating understanding in this field, particularly in the yeast Saccharomyces cerevisiae.