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Apoliprotein locus

Jonathan B Weitzman

Author Affiliations

Genome Biology 2001, 2:spotlight-20011010-01  doi:10.1186/gb-spotlight-20011010-01

The electronic version of this article is the complete one and can be found online at:


Published:10 October 2001

© 2001 BioMed Central Ltd

Research news

In the October 5 Science, Len Pennacchio and colleagues, at the Lawrence Berkeley National Laboratory in California, describe how interspecies sequence comparison of the human and mouse apolipoprotein gene cluster (APOAI/CIII/AIV) led to the identification of a novel apolipoprotein-like gene (APOAV)(Science 2001, 294:169-173). Transgenic mice overexpressing the human APOAV gene have reduced plasma triglyceride levels, whereas APOAV-deficient knockout animals had four-times higher levels than controls. Pennacchio et al. found that single nucleotide polymorphisms (SNPs) in the human APOAV gene were linked to changes in plasma triglyceride levels. Thus, APOAV polymorphisms may serve as prognostic indicators for hypertriglyceridemia susceptibility and cardiovascular disease risk. The authors emphasize that comparative sequence analysis was key to the identification of APOAV.

References

  1. [http://www.sciencemag.org] webcite

    Science

  2. [http://www.lbl.gov] webcite

    Lawrence Berkeley National Laboratory

  3. [http://pga.lbl.gov/] webcite

    Comparative genomic analysis of cardiovascular gene regulation

  4. Human apolipoprotein A-I--C-III gene complex is located on chromosome 11

    PubMed Abstract OpenURL