Email updates

Keep up to date with the latest news and content from Genome Biology and BioMed Central.

Research news

All about abo

Jonathan B Weitzman

Author Affiliations

Genome Biology 2001, 2:spotlight-20011017-02  doi:10.1186/gb-spotlight-20011017-02


The electronic version of this article is the complete one and can be found online at:


Published:17 October 2001

© 2001 BioMed Central Ltd

Research news

Mutation of the Drosphila abnormal oocyte (abo) gene causes a recessive maternal-effect lethality, which can be rescued by specific regions of heterochromatin. In the October 9 Proceedings of the National Academy of Sciences, Berloco et al. report a characterization of the abo protein product and its function (Proc Natl Acad Sci USA 2001, 98:12126-12131). They cloned the abo gene and showed that it encodes a chromosomal protein that binds specifically to the regulatory regions within the histone gene cluster (on the 39E region of polytene chromosomes). Similar proteins were found in Arabidopsis (the DET1 protein), as well as in mouse and man. Chromatin immunoprecipitation experiments demonstrated that Abo binds to the histone gene promoter regions, and abo mutations affected histone expression levels. Deleting the histone cluster rescued the abo maternal-effect defects. The authors conclude that Abo is a negative regulator of histone gene expression.

References

  1. Developmental genetical analysis and molecular cloning of the abnormal oocyte gene of Drosophila melanogaster

    PubMed Abstract OpenURL

  2. [http://www.pnas.org] webcite

    Proceedings of the National Academy of Sciences