Genome Biology
Volume 2
Issue 11 |
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MinireviewHIV: master of the host cellChristopher W Arendt and Dan R Littman  Howard Hughes Medical Institute, Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University Medical Center, New York, NY 10016, USA  author email corresponding author email
Genome Biology 2001,
2:reviews1030.1-1030.4doi:10.1186/gb-2001-2-11-reviews1030
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22 October 2001 |
Subject areas: Virology, Immunology, Medicine, Cell biology, Genome studies Abstract
The human immunodeficiency virus has evolved various mechanisms to exploit its host cells, including the interruption and augmentation of signal transduction pathways. Recently, two DNA microarray studies have illustrated a remarkably broad-based perturbation in host transcriptional responses, which is in part mediated by the HIV-encoded Nef protein. HIV therefore seems to function as a 'master regulator' of cellular gene expression. | 
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