HOMOPHILA is a searchable database of human disease genes, obtained from the Online Mendelian Inheritance in Man database, that have significant homology at the protein level to genes contained in FlyBase, the current Drosophila sequence database. Of the 920 gene entries contained in OMIM, 708 (77%) had strong matches to sequences in the Drosophila database. There are in-site links to 'Known alleles', 'Disease categories' and 'Signaling pathway homologs', which display subsets of the data. There is also a page that displays the number of Drosophila sequences related to human disease genes as a function of the BLAST similarity e-value in a graphical format.
Navigation through the site is easy. At the bottom of the homepage is a simple search engine using a keyword search with drag-down options. An example query is also provided, on the list of links running down the right-hand side of the main page.
According to the website the data are updated monthly.
As a fan of simple search engines, I rate this one highly.
The search engine doesn't allow Boolean searches, so each gene or homolog has to be searched for individually