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Intraepithelial gamma delta T cells exposed by functional genomics

Richard Boismenu1 and Wendy L Havran2*

Author Affiliations

1 Repligen Corporation, Fourth Avenue, Needham, MA 02494, USA

2 Department of Immunology, The Scripps Research Institute, North Torrey Pines Road, La Jolla, CA 92037, USA

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Genome Biology 2001, 2:reviews1031-reviews1031.4  doi:10.1186/gb-2001-2-11-reviews1031

Published: 22 October 2001

Abstract

Epithelial tissues house γδ T cells, which are important for the mucosal immune system and may be involved in controlling malignancies, infections and inflammation. Whole-genome gene-expression analysis provides a new way to study the signals required for the activation of γδ T cells, their mode of action and relationships among cells of the mucosal immune system.