Intraepithelial gamma delta T cells exposed by functional genomics
1 Repligen Corporation, Fourth Avenue, Needham, MA 02494, USA
2 Department of Immunology, The Scripps Research Institute, North Torrey Pines Road, La Jolla, CA 92037, USA
Genome Biology 2001, 2:reviews1031-reviews1031.4 doi:10.1186/gb-2001-2-11-reviews1031Published: 22 October 2001
Epithelial tissues house γδ T cells, which are important for the mucosal immune system and may be involved in controlling malignancies, infections and inflammation. Whole-genome gene-expression analysis provides a new way to study the signals required for the activation of γδ T cells, their mode of action and relationships among cells of the mucosal immune system.