Email updates

Keep up to date with the latest news and content from Genome Biology and BioMed Central.

Research news

Light-induced apoptosis

Jonathan B Weitzman

Genome Biology 2001, 2:spotlight-20011105-01  doi:10.1186/gb-spotlight-20011105-01

The electronic version of this article is the complete one and can be found online at:


Published:5 November 2001

© 2001 BioMed Central Ltd

Research news

Exposure to light induces photoreceptor cell death and retinal degeneration in animal models. The absence of some genes (for example, arrestin or rhodopsin kinase) can sensitize the retina to light damage. In the November 6 Proceedings of the National Academy of Sciences, Sangdun Choi and researchers at the California Institute of Technology report the use of gene expression profiling to investigate light-induced apoptosis (Proc Natl Acad Sci USA 2001, 98:13096-13101). They isolated retinal tissue from arrestin/rhodopsin kinase double-knockout mice that had been raised in the dark and exposed to moderate-intensity light for different amounts of time. Oligonucleotide microarray analysis identified thousands of genes that change upon light exposure, including many components of the phototransduction cascade. The genes could be divided into a number of different clusters. Changes in transcript levels often preceded evidence of morphological damage, but they observed surprisingly few changes in genes implicated in the induction of apoptosis.

References

  1. Apoptotic cell death in retinal degenerations.

    PubMed Abstract | Publisher Full Text OpenURL

  2. Abnormal photoresponses and light-induced apoptosis in rods lacking rhodopsin kinase.

    PubMed Abstract | Publisher Full Text | PubMed Central Full Text OpenURL

  3. [http://www.pnas.org] webcite

    Proceedings of the National Academy of Sciences

  4. [http://www.caltech.edu] webcite

    California Institute of Technology

  5. [http://microarray.caltech.edu/pubs] webcite

    Publications using microarray techniques