More genes on the fly Y
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Correspondence: Jonathan B Weitzman jonathanweitzman@hotmail.com
Genome Biology 2001, 2:spotlight-20011106-01 doi:10.1186/gb-spotlight-20011106-01
The electronic version of this article is the complete one and can be found online at:
| Published: | 6 November 2001 |
© 2001 BioMed Central Ltd
Research news
The Drosophila Y chromosome has several features (including its heterochromatic state) that have made mapping and sequencing difficult. The Y chromosome contains genes directly involved with male fertility. In the November 6 Proceedings of the National Academy of Sciences, Carvalho et al. describe a search for more novel Y-linked genes (Proc Natl Acad Sci USA 2001, 98:13225-13230). They used a strategy involving staggered TBLASTN screening of 500,000 proteins against the armU database of unmapped Drosophila sequences. This led to the identification of five novel Y-linked genes; three of these encode serine-threonine protein phosphatases, one is related to occludin and the other encodes a coiled-coil protein. This study raises the number of identified single-copy genes on the Y chromosome to nine.
References
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Proceedings of the National Academy of Sciences
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Y chromosomal fertility factors kl-2 and kl-3 of Drosophila melanogaster encode dynein heavy chain polypeptides.
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