Table 1 |
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Functions of hormone receptors in family B1 |
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| Gene name |
Gene product |
Ligand(s), with the name of the precursor gene in italics, where it is different |
Principal functions controlled by the receptor |
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| SCTR |
Secretin receptor |
Secretin (SCT) |
Secretion of HCO3-, enzymes, and K+ by the pancreas [41] |
| VIPR1 |
VPAC1 receptor |
VIP, PACAP (ADCYAP1) |
Neuromodulation, T-cell differentiation |
| VIPR2 |
VPAC2 receptor |
VIP, PACAP (ADCYAP1) |
Circadian rhythms [42] |
| ADCYAP1R1 |
PAC1 receptor |
PACAP (ADCYAP1) |
Glucose homeostasis, nociception, learning and memory, circadian rhythms [29-33] |
| GCGR |
Glucagon receptor |
Glucagon (GCG) |
Hepatic glycogenolysis and gluconeogenesis, pancreatic secretion of insulin [41] |
| GHRHR |
Growth hormone releasing hormone (GHRH) receptor |
GHRH |
Release of pituitary growth hormone [41] |
| GLP1R |
Glucagon-related peptide 1 (GLP-1) receptor |
GLP-1 (GCG) |
Pancreatic secretion of insulin and glucagon [41] |
| GLP2R |
Glucagon-related peptide 2 (GLP-2) receptor |
GLP-2 (GCG) |
Proliferation of intestinal mucosal villus epithelium [41] |
| GIPR |
Gastric inhibitory polypeptide (GIP) receptor |
GIP |
Pancreatic secretion of insulin [41] |
| CRHR1 |
corticotropin releasing factor 1 (CRF1) receptor |
CRF (CRH), urocortin (UCN) |
Secretion of ACTH [21] |
| CRHR2 |
Corticotropin releasing factor 2 (CRF2) receptor |
Urocortin (UCN), urocortin II, urocortin III, perhaps CRF (CRH) |
Stress-related autonomic, neuroendocrine, and behavioral function [21] |
| PTHR1 |
Parathyroid hormone 1 (PTH1) receptor |
Parathyroid hormone, PTH-related peptide (PTHLH) |
Calcium homeostasis in bone and kidney; skeletal, pancreatic, epidermal and mammary
gland differentiation [43,44] |
| PTHR2 |
Parathyroid hormone 2 (PTH2) receptor |
TIP39 [22] |
Unknown |
| CALCRL |
Calcitonin receptor-like receptor |
Calcitonin gene related peptide (CGRP: CALCA, CALCB)*; adrenomedullin†‡(ADM) |
Vascular tone |
| CALCR |
Calcitonin receptor |
Calcitonin†‡ (CALCA) amylin*‡ (IAPP) CGRP*(CALCA, CALCB) |
Calcitonin: calcium homeostasis in bone and kidney; amylin: postprandial glucagon
secretion, nutrient transit through the stomach |
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*When formed with accessory protein RAMP1 [23,24]; †when formed with accessory protein RAMP2 [23,24]; ‡when formed with accessory protein RAMP3 [23,24]. VIP, vasoactive intestinal peptide; PACAP, pituitary adenylate cyclase-activating polypeptide; ADCYAPR1R1, adenylate cyclase activating polypeptide 1 receptor 1. |
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Harmar Genome Biology 2001 2:reviews3013.1 doi:10.1186/gb-2001-2-12-reviews3013 |
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