Table 1 |
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Properties of granzymes in humans and rodents |
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| Granzyme |
Species |
Activity |
Predicted cleavage |
Mr (× 103) |
Cellular expression |
|
|
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| A |
Mouse, human, rat |
Tryptase |
Lysine, arginine |
65* |
CTLs, NK cells, γδ T cells and thymocytes |
| B |
Mouse, human, rat |
Asp-ase |
Aspartic acid > glutamic acid |
32 |
CTLs, NK cells, γδ T cells and thymocytes |
| C |
Mouse, rat |
Unknown |
Asparagine or serine |
27 |
CTLs |
| D |
Mouse |
Unknown |
Hydrophobic |
35-50 |
CTLs |
| E |
Mouse |
Unknown |
Hydrophobic |
35-45 |
CTLs |
| F |
Mouse, rat |
Unknown |
Hydrophobic |
35-50 |
CTLs |
| G |
Mouse |
Unknown |
Hydrophobic |
30 |
CTLs |
| H |
Human |
Chymase |
Phenylalanine > tyrosine |
32 |
CTLs and NK cells |
| J |
Rat |
Unknown |
Unknown |
30 |
Unknown |
| M |
Mouse, human, rat |
Met-ase |
Methionine > leucine |
30 |
NK cells |
|
|
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*Granzyme A is the only granzyme that is found as a homodimer and its relative molecular mass (Mr) is therefore higher. |
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|
Trapani Genome Biology 2001 2:reviews3014.1 doi:10.1186/gb-2001-2-12-reviews3014 |
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