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Homologuephobia

Gregory A Petsko

Genome Biology 2001, 2:comment1002-comment1002.2 doi:10.1186/gb-2001-2-2-comment1002

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Using orthologous and paralogous proteins to identify specificity determining residues

Leonid A Mirny, Mikhail S Gelfand Genome Biology 2002, 3:preprint0002-preprint0002.20 (19 February 2002)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Functional specificity of proteins is assumed to be conserved among orthologs and to be different among paralogs. We used this assumption to identify the residues that determine specificity of protein-DNA and protein-ligand recognition and present a method to compute the statistical significance of the predictions.

Correspondence   Free Highly Accessed

Orthologs and paralogs - we need to get it right

Roy A Jensen Genome Biology 2001, 2:interactions1002-interactions1002.3 (3 August 2001)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

A response to Homologuephobia, by Gregory A Petsko, Genome Biology 2001 2:comment1002.1-1002.2, to An apology for orthologs - or brave new memes by Eugene V Koonin, Genome Biology 2001, 2:comment1005.1-1005.2, and to Can sequence determine function? by John A Gerlt and Patricia C Babbitt, Genome Biology 2000, 1:reviews0005.1-0005.10.

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