Genome Biology

official impact factor 6.89

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Protein microarrays for highly parallel detection and quantitation of specific proteins and antibodies in complex solutions

Brian B Haab, Maitreya J Dunham and Patrick O Brown*

Genome Biology 2001, 2:research0004-research0004.13 doi:10.1186/gb-2001-2-2-research0004

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BioMed Central: 9 citations

Research article   Open Access

Epitope spreading to citrullinated antigens in mouse models of autoimmune arthritis and demyelination

Brian A Kidd, Peggy P Ho, Orr Sharpe, Xiaoyan Zhao, Beren H Tomooka, Jennifer L Kanter, Lawrence Steinman, William H Robinson Arthritis Research & Therapy 2008, 10:R119 (30 September 2008)

Database   Open Access Highly Accessed

AbMiner: A bioinformatic resource on available monoclonal antibodies and corresponding gene identifiers for genomic, proteomic, and immunologic studies

Sylvia M Major, Satoshi Nishizuka, Daisaku Morita, Rick Rowland, Margot Sunshine, Uma Shankavaram, Frank Washburn, Daniel Asin, Hosein Kouros-Mehr, David Kane, John N Weinstein BMC Bioinformatics 2006, 7:192 (6 April 2006)

The AbMiner database provides extensive information on more than 600 monoclonal antibodies and their antigens, validated in 60 cell lines from nine different tissues, and links to a variety of genomic and proteomic databases.

Research article   Open Access Highly Accessed

Distinctive serum protein profiles involving abundant proteins in lung cancer patients based upon antibody microarray analysis

Wei-Min Gao, Rork Kuick, Randal P Orchekowski, David E Misek, Ji Qiu, Alissa K Greenberg, William N Rom, Dean E Brenner, Gilbert S Omenn, Brian B Haab, Samir M Hanash BMC Cancer 2005, 5:110 (23 August 2005)

Methodology article   Open Access Highly Accessed

Miniaturized fluorescent RNA dot blot method for rapid quantitation of gene expression

Fekadu Yadetie, Arne K Sandvik, Hallgeir Bergum, Kristin Norsett, Astrid Laegreid BMC Biotechnology 2004, 4:12 (10 June 2004)

Method   Open Access Highly Accessed

Two-color, rolling-circle amplification on antibody microarrays for sensitive, multiplexed serum-protein measurements

Heping Zhou, Kerri Bouwman, Mark Schotanus, Cornelius Verweij, Jorge A Marrero, Deborah Dillon, Jose Costa, Paul Lizardi, Brian B Haab Genome Biology 2004, 5:R28 (30 March 2004)

Two-color rolling-circle amplification on antibody microarrays produces a 30-fold higher fluorescence than direct-labeling and indirect-detection methods, allowing acquisition of expression profiles from a great diversity of proteins.

Review   Open Access Highly Accessed

Protein expression profiling arrays: tools for the multiplexed high-throughput analysis of proteins

Jens R Sydor, Steffen Nock Proteome Science 2003, 1:3 (10 June 2003)

Software   Open Access Highly Accessed

BioArray Software Environment (BASE): a platform for comprehensive management and analysis of microarray data

Lao H Saal, Carl Troein, Johan Vallon-Christersson, Sofia Gruvberger, Åke Borg, Carsten Peterson Genome Biology 2002, 3:software0003-software0003.6 (15 July 2002)

The microarray technique requires the organization and analysis of vast amounts of data. These data include information about the samples hybridized, the hybridization images and their extracted data matrices, and information about the physical array, the features and reporter molecules. We present a web-based customizable bioinformatics solution called BioArray Software Environment (BASE) for the management and analysis of all areas of microarray experimentation. All software necessary to run a local server is freely available.

Review   Free

Autoantibody profiling for the study and treatment of autoimmune disease

Wolfgang Hueber, Paul J Utz, Lawrence Steinman, William H Robinson Arthritis Res 2002, 4:290-295 (7 May 2002)

Opinion   Free

Chemical genomics: what will it take and who gets to play?

Gavin MacBeath Genome Biology 2001, 2:comment2005-comment2005.6 (6 June 2001)

Chemical genomics requires continued advances in combinatorial chemistry, protein biochemistry, miniaturization, automation, and global profiling technology, and will require large, well-funded centers to integrate these components and freely distribute data and reagents.