Genome Biology

official impact factor 6.89
Search for
Advanced search
Genome Biology
Tools
Open Access

Use of molecular beacons to verify that the serine hydroxymethyltransferase pseudogene SHMT-ps1 is unique to the order Primates

Eric J Devor

Genome Biology 2001, 2:research0006-research0006.5 doi:10.1186/gb-2001-2-2-research0006

Accesses  

  • Last 30 days: 25 accesses
  • Last year: 253 accesses
  • All time: 5408 accesses

Cited by

BioMed Central: 1 citation

Research   Open Access

Molecular archeology of an SP100 splice variant revisited: dating the retrotranscription and Alu insertion events

Eric J Devor Genome Biology 2001, 2:research0040-research0040.6 (30 August 2001)

Abstract | Full text | PDF | PubMed | Editor’s summary

PCR amplification of the 3' end of the nuclear protein encoding gene SP100 using genomic DNAs from human and New World and Old World monkey species, followed by sequencing of the amplicons, has made dating the HMG1L3 and Alu insertion events possible. The HMG1L3 retrotransposition into the SP100 locus occurred after divergence of New World and Old World monkey lineages, some 35-40 million years ago. An upstream Alu sequence was inserted in the last SP100-HMG intron after divergence of the Old World monkey and ape lineages. Sequencing of the Alu in five Old World monkey species places this event at around 19 million years ago.

Google Scholar: View citations

PubMed Central: View citations