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High-throughput reverse genetics: RNAi screens in Caenorhabditis elegans
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Correspondence: Cornelia I Bargmann cori@itsa.ucsf.edu
Howard Hughes Medical Institute, Departments of Anatomy and of Biochemistry and Biophysics, The University of California, San Francisco, CA 94143, USA
Genome Biology 2001, 2:reviews1005-reviews1005.3 doi:10.1186/gb-2001-2-2-reviews1005
Published: 31 January 2001Abstract
Two recent chromosome-wide screens for phenotypes caused by RNA-mediated interference (RNAi) in Caenorhabditis elegans have increased our understanding of essential genes in nematodes. These papers represent a major advance in functional genomics.