Genome Biology

official impact factor 6.89

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Control of eukaryotic transcription elongation

Fred Winston

Author Affiliations

Department of Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA

Genome Biology 2001, 2:reviews1006-reviews1006.3 doi:10.1186/gb-2001-2-2-reviews1006

Published: 31 January 2001

Abstract

The Spt4, Spt5, and Spt6 proteins are conserved eukaryotic transcription-elongation factors. Recent studies have provided the first evidence that they are generally required in multicellular eukaryotes, including during development and for viral gene expression.