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Ontological classification of 22,339 human gene products. Each transcriptional unit and HINT transcript (in parentheses) was assigned to a unique biological function or process. |
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| Biological function |
Number of transcripts |
Biological process |
Number of transcripts |
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| Transcription factor |
958 (306) |
Carbohydrate metabolism |
281 (84) |
| Translation factor |
62 (27) |
Nucleotide and nucleic acid metabolism |
173 (51) |
| RNA binding |
142 (41) |
DNA replication |
240 (126) |
| Ribosomal protein |
232 (130) |
Transcription |
1,059 (651) |
| Cell cycle regulator |
42 (16) |
RNA processing |
204 (59) |
| Structural protein |
145 (48) |
Amino Acid and derivative metabolism |
87 (29) |
| Cytoskeleton structural protein |
329 (181) |
Protein biosynthesis |
264 (162) |
| Extracellular matrix |
361 (87) |
Protein modification |
235 (88) |
| Actin binding |
66 (25) |
Protein targeting |
26 (5) |
| Motor protein |
245 (77) |
Protein degradation |
136 (45) |
| Chaperone |
87 (27) |
Proteolysis and peptidolysis |
96 (36) |
| Enzyme |
2,664 (1,404) |
Lipid metabolism |
424 (187) |
| Protein kinase |
895 (484) |
Monocarbon compound metabolism |
9 (3) |
| Protein kinase inhibitor |
19 (12) |
Coenzyme and prosthetic group metabolism |
92 (29) |
| Protein phsophatase |
43 (7) |
Steroid compound metabolism |
40 (10) |
| Protein phsophatase inhibitor |
17 (3) |
Prostaglandin metabolism |
12 (3) |
| Protease |
441 (255) |
Transport |
549 (288) |
| Protease inhibitor |
92 (37) |
Electron transport |
491 (273) |
| Enzyme activator |
18 (3) |
Ion transport |
302 (90) |
| Enzyme inhibitor |
14 (4) |
Small molecular transport |
19 (9) |
| Alkyl transfer |
17 (3) |
Neurotransmitter transport |
9 (3) |
| Amide transfer |
15 (3) |
Ion homeostasis |
201 (57) |
| Carbonyl transfer |
191 (38) |
Organelle organization and biogenesis |
408 (254) |
| Hydroxyl transfer |
13 (6) |
Nuclear organization and biogenesis |
1,380 (647) |
| Phosphoryl transfer |
823 (281) |
Cytoplasm organization and biogenesis |
42 (20) |
| Oxireduction |
148 (76) |
Meiosis |
15 (2) |
| Transmembrane protein |
184 (48) |
Mitosis |
25 (6) |
| Receptor |
921 (478) |
Cell cycle |
271 (100) |
| G protein-linked receptor |
164 (106) |
DNA packaging |
15 (6) |
| Defense/immunity protein |
353 (164) |
DNA repair |
132 (41) |
| Ligand binding or carrier |
691 (331) |
DNA recombination |
31 (3) |
| Ion channel |
245 (141) |
Methylation |
185 (53) |
| Oncogene |
128 (42) |
Signal transduction |
1,231 (383) |
| Tumor suppressor |
8 (6) |
Growth regulation |
15 (4) |
| Growth factor |
95 (40) |
Differentiation |
24 (6) |
| Hormone |
42 (14) |
Apoptosis |
160 (49) |
| Cell communication |
247 (84) |
Angiogenesis |
11 (4) |
| Cell adhesion |
433 (252) |
Defense/immunity |
112 (49) |
| Detoxification |
33 (15) |
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| Stress response |
90 (41) |
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| Developmental process |
278 (99) |
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| Neurogenesis and regeneration |
147 (43) |
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| Physiological process |
159 (43) |
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| Sensory perception |
292 (65) |
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| Functionally classified |
12,334 (5,204) |
Process classified |
10,005 (4,225) |
Wright et al. Genome Biology 2001 2:preprint0001.1 doi:10.1186/gb-2001-2-3-preprint0001 |
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