Genome Biology

official impact factor 6.89

Comment

Size doesn't matter

Gregory A Petsko

Author Affiliations

Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, MA 02454-9110, USA

Genome Biology 2001, 2:comment1003-comment1003.2 doi:10.1186/gb-2001-2-3-comment1003

Published: 28 February 2001

First paragraph (this article has no abstract)

So now we know. The first 'official' count of the number of genes in the human genome is in, and the total is smaller than almost anyone had imagined. Sorting out the pseudogenes from the real ones will take some time, so the number may increase a bit, but it seems clear that the genome of Homo sapiens contains fewer than 40,000 genes, with the final number probably being closer to 30,000. Quibble about the exact count if you will, but the total will probably not approach even half the 80,000-100,000 estimate that was widely bandied about when the Human Genome Project began.