Nuclear dynamics: where genes are and how they got there
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* Corresponding author: Jason R Swedlow j.swedlow@dundee.ac.uk
Division of Gene Regulation and Expression, Wellcome Trust Biocentre, University of Dundee, Dow Street, Dundee, DD1 5EH, UK
Genome Biology 2001, 2:reviews0002-reviews0002.7 doi:10.1186/gb-2001-2-3-reviews0002
Published: 9 March 2001Abstract
DNA is highly organized spatially, both within domains of chromatin along each chromosome and within the nucleus as a whole. Recent studies suggest that chromatin localization can affect transcriptional and replicational activity. The similarity between the movements of chromatin nuclear bodies suggests a common mechanism that regulates nuclear dynamics.