Table 2

FGF knockout mice

Gene

Survival of null mutant*

Phenotype

References


Fgf1

Viable

None identified

[110]

Fgf2

Viable

Mild cardiovascular, skeletal, neuronal

[110,111,112,113,114]

Fgf3

Viable

Mild inner ear, skeletal (tail)

[115]

Fgf4

Lethal, E4-5

Inner cell mass proliferation

[116]

Fgf5

Viable

Long hair, angora mutation

[72]

Fgf6

Viable

Subtle, muscle regeneration

[117,118,119]

Fgf7

Viable

Hair follicle growth, ureteric bud growth

[120,121]

Fgf8

Lethal, E7

Gastrulation defect, CNS development, limb development

[67,70,122,123]

Fgf9

Lethal, P0

Lung mesenchyme, XY sex reversal

[124]; (J.S. Colvin et al., personal communication)

Fgf10

Lethal, P0

Development of multiple organs, including limb, lung, thymus, pituitary

[125,126,127]

Fgf12 (Fhf1)

Viable

Neuromuscular phenotype

(J. Schoorlemmer and M. Goldfarb, personal communication)

Fgf14 (Fhf4)

Viable

Neurological phenotypes

(Q. Wang, personal communication)

Fgf15

Lethal, E9.5

Not clear

(J.R. McWhirter, personal communication)

Fgf17

Viable

Cerebellar development

[17]

Fgf18

Lethal, P0

Skeletal development

(N. Ohbayashi, Z. Liu, personal communication)


*E, embryonic day; P, postnatal day.

Ornitz and Itoh Genome Biology 2001 2:reviews3005.1-reviews3005.12   doi:10.1186/gb-2001-2-3-reviews3005