A tale of histone modifications

doi:10.1186/gb-2001-2-4-reviews0003

Genome Biology

Volume 2
Issue 4

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Review

A tale of histone modifications

Patrick A Grant

Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Jefferson Park Avenue, Charlottesville, VA 22908, USA

author email corresponding author email

Genome Biology 2001, 2:reviews0003.1-0003.6doi:10.1186/gb-2001-2-4-reviews0003


Published:	5 April 2001

Subject areas: Molecular biology, Biochemistry and structural biology, Cell biology, Genetics

Abstract

The modification of chromatin structure is important for a number of nuclear functions, exemplified by the regulation of transcription. This review discusses recent studies of covalent histone modifications and the enzymatic machines that generate them.