Table 5

Violations of Chargaff's rule and rate constancy

|slope A/B|

|slope E|

Error

T1

0.251

0.248

6.591

C1

0.421

0.382

4.640

A1

0.466

0.334

2.474

G1

0.296

0.201

3.930

T2

0.095

0.126

7.738

C2

0.221

0.217

5.256

A2

0.333

0.254

11.984

G2

0.207

0.163

7.487

T3

0.938

0.986

0.065

C3

1.108

1.212

0.065

A3

0.917

1.051

0.076

G3

0.746

0.825

0.082

|slope AB| is the absolute value of the change of a given nucleotide at a given position (relative to total coding sequence GC content) in archaea/bacteria; |slope E| is the corresponding slope in eukaryotes. Error is a measure of the average consequence of a change in a particular base at a particular codon position (for example, T1 is T at the first position, using a methodology based on [69]. See text for explanation.

Knight et al. Genome Biology 2001 2:research0010.1   doi:10.1186/gb-2001-2-4-research0010