A tale of histone modifications
Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Jefferson Park Avenue, Charlottesville, VA 22908, USA
Genome Biology 2001, 2:reviews0003-reviews0003.6 doi:10.1186/gb-2001-2-4-reviews0003Published: 5 April 2001
The modification of chromatin structure is important for a number of nuclear functions, exemplified by the regulation of transcription. This review discusses recent studies of covalent histone modifications and the enzymatic machines that generate them.