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The origin of HIV-1

Kenneth Lee

Author Affiliations

Genome Biology 2001, 2:spotlight-20010427-01  doi:10.1186/gb-spotlight-20010427-01


The electronic version of this article is the complete one and can be found online at:


Published:27 April 2001

© 2001 BioMed Central Ltd

Research news

The origin of the human immunodeficiency virus HIV-1 is controversial. In his 1999 book The River: A Journey Back to the Source of HIV and AIDS, journalist Edward Hooper claimed that the chimpanzee simian immunodeficiency virus, the closest relative of HIV-1, was transferred to humans in the Congo between 1957 and 1960 via an oral vaccine against the polio virus. Hooper believes that chimpanzee kidney cultures were used in the preparation of the vaccine. In the 26 April Nature, three independent studies provide evidence that effectively dismiss this claim.

Berry et al. subjected two frozen stocks of the suspect vaccine to PCR analysis. They detected neither human nor simian immunodeficiency virus sequences (Nature 2001, 410:1046-1047). Instead, they found evidence of macaque mitochondrial sequences, suggesting that the vaccine was prepared from macaque, not chimpanzee cells.

In the second study, Blancou et al. performed a similar analysis on five frozen stocks of the vaccine, one of which was used to vaccinate 75,000 people in LĂ©opoldville in the former Belgian Congo. No sample proved positive for HIV-1 or simian immunodeficiency virus. Again, only macaque mitochondrial DNA sequences were detected (Nature 2001, 410:1045-1046).

Rambaut et al. undertook a phylogenetic study of 197 HIV-1 sequences sampled from the Congo and 223 sequences representing the global diversity of HIV-1 (including all known subtypes). Their study identified the last common ancestor of the main group of HIV-1 viruses (group 'M', the viruses responsible for the majority of AIDS cases) as a virus present in a human host, rather than being transferred from another primate (Nature 2001, 410:1047-1048).

References

  1. [http://www.the-scientist.com/news/20000912/02] webcite

    'Origin of AIDS: debate intensifies' BioMed Central 12 September 2000

  2. [http://www.nature.com/nature/] webcite

    Berry N, Davis C, Jenkins A, Wood D, Minor P, Schild G, Bottinger M, Holmes H, Almond N: Analysis of oral polio vaccine CHAT stocks. Nature 2001, 410:1046-1047.

  3. [http://www.nature.com/nature/] webcite

    Blancou P, Vartanian J-P, Christopherson C, Chenciner N, Basilico C, Kwok S, Wain-Hobson S: Polio vaccine samples not linked to AIDS. Nature 2001, 410:1045-1046.

  4. [http://www.nature.com/nature/] webcite

    Rambaut A, Robertson DL, Pybus OG, Peeters M, Holmes EC: Phylogeny and the origin of HIV-1. Nature 2001, 410:1047-1048.

  5. [http://www.penguin.co.uk/] webcite

    Hooper E: The River: A Journey Back to the Source of HIV and AIDS. London: Penguin, 1999.